In what condition might one expect to find hypotonia as a significant physical feature?

Hypotonia, or decreased muscle tone, is notably associated with Down Syndrome, which is a genetic condition caused by the presence of an extra chromosome 21. Infants and children with Down Syndrome often exhibit hypotonia, which can affect their muscle strength and developmental milestones. This characteristic can affect their ability to suck and swallow effectively, as well as their overall mobility and coordination.

In the context of the other conditions, while hypotonia can be present in some cases, it is not as prominently or as consistently recognized as in Down Syndrome. Turner Syndrome, for instance, primarily involves developmental issues and physical features related to short stature and ovarian dysfunction, rather than significant hypotonia. Edward's Syndrome and Patau Syndrome also have a range of life-threatening abnormalities and developmental delays, but hypotonia is not a hallmark feature as it is in Down Syndrome.

Thus, the prominent and consistent observation of hypotonia in infants with Down Syndrome makes it the most plausible answer for conditions where hypotonia is a significant physical feature.