What characterizes meconium plug syndrome?

Meconium plug syndrome is characterized primarily by abnormal gut motility, which is often attributed to the immaturity of the intestines in neonates. In this condition, the meconium (the first stool of an infant) can become thickened or retained, leading to a blockage in the intestines due to inefficient peristalsis and transit. This is commonly seen in premature infants or those who have not fully developed gut function, thereby affecting their ability to effectively pass meconium.

Infants with this syndrome may exhibit signs of intestinal obstruction, such as abdominal distension and vomiting. The underlying issue is that the immature gut may not be able to push the meconium through effectively, contributing to the accumulation and potential obstruction. Understanding this pathophysiology is crucial in recognizing and managing meconium plug syndrome, thus making abnormal gut motility due to immaturity a defining characteristic of the condition.