What is the ANC count threshold that suggests the possibility of infection?

The threshold for the absolute neutrophil count (ANC) that indicates a significant risk of infection in neonates is typically 1500 cells per microliter. In the neonatal population, an ANC below this level suggests that the infant may not have sufficient neutrophils to effectively combat infections, increasing the likelihood of severe infection or sepsis. The neutrophils play a critical role in the immune response, providing a primary defense against bacterial and fungal pathogens.

Infants with an ANC lower than 1500 may require close monitoring and potential intervention, such as administration of antibiotics or other supportive care, to prevent or treat any emerging infections. This threshold is a vital part of routine assessments in the NICU and helps guide clinical decisions based on the infant's risk factors and overall clinical picture. Regular evaluation of ANC in this population is crucial, given their vulnerability to infections and often compromised immune systems.