What is the primary causative organism associated with early onset sepsis in neonates?

The primary causative organism associated with early onset sepsis in neonates is Escherichia coli. This bacterium is commonly found in the gastrointestinal tract of humans and can be a significant pathogen in newborns, particularly those who are premature or have low birth weight.

In cases of early onset sepsis, which typically occurs within the first 72 hours of life, E. coli can be transmitted from the mother during labor, especially if there are risk factors such as prolonged rupture of membranes or maternal urinary tract infections. This organism is known for causing systemic infections and can lead to severe outcomes if not promptly identified and treated.

Understanding the predominant pathogens responsible for early onset sepsis helps healthcare practitioners in making informed decisions about prophylactic measures and timely interventions, including the initiation of appropriate antibiotic therapy in at-risk neonates.