What might a persistent rise in C-reactive protein indicate?

A persistent rise in C-reactive protein (CRP) is most indicative of ongoing inflammation, which can suggest the presence of an underlying infection. This is particularly relevant in scenarios such as chronic infections or conditions like meningitis, where an immune response is continually activated. C-reactive protein is an acute-phase reactant that increases in response to inflammation, and its elevated levels can signify that the body is still fighting an infection or dealing with significant inflammatory processes.

In cases of chronic infection, CRP levels may remain elevated due to the continual presence of pathogens or ongoing inflammatory processes, indicating that the infection has not been resolved. Similarly, in meningitis – particularly if it is bacterial – the persistent inflammation due to the infection's effects on the meninges can also lead to sustained elevation in CRP levels.

Monitoring CRP levels can help healthcare providers assess the effectiveness of treatment. A decrease in CRP after starting therapy typically indicates a positive response, while continued elevation suggests inadequate treatment or an ongoing infection. This makes CRP a valuable marker in the clinical setting for evaluating the severity and resolution of infections.