What significant risk factor is associated with duodenal atresia?

Polyhydramnios is the correct answer because it is significantly associated with duodenal atresia. This condition often leads to an accumulation of amniotic fluid during pregnancy, as the fetus is unable to properly swallow and process the amniotic fluid due to gastrointestinal obstruction caused by the atresia.

In the context of duodenal atresia, the inability to pass fluid through the gastrointestinal tract results in an increased amount of fluid in the amniotic sac, leading to polyhydramnios. This finding is commonly observed in prenatal ultrasounds, which can help in the early identification of potential congenital anomalies like duodenal atresia.

Low birth weight, hypoglycemia, and hyperbilirubinemia are not directly associated with duodenal atresia as significant risk factors. While these conditions can occur in neonates with various health issues, they do not have the same direct correlation with the presence of duodenal atresia as polyhydramnios does. Understanding these relationships is essential for recognizing potential complications and planning appropriate care for affected infants.