What symptom may indicate the development of shock in a neonate with PPHN?

Hypotension is a critical symptom that may indicate the development of shock in a neonate with Persistent Pulmonary Hypertension of the Newborn (PPHN). In this condition, blood flow is redirected away from systemic circulation due to elevated pulmonary pressures, leading to decreased perfusion to vital organs. As a result, the infant may experience a drop in blood pressure, which is a direct indicator of inadequate blood volume and perfusion, ultimately resulting in shock.

Monitoring blood pressure in neonates is essential, especially in the context of PPHN, as any persistence of hypotension can signify that the body's compensatory mechanisms are failing, thereby suggesting a more severe underlying issue requiring immediate intervention. Recognizing hypotension in this context is crucial for timely management to prevent further deterioration of the neonate's condition.