Which condition is linked with a significant risk of hypoglycemia?

Beckwith-Wiedemann Syndrome is indeed linked with a significant risk of hypoglycemia due to the hyperinsulinemic state often seen in affected infants. This genetic disorder, characterized by overgrowth and an increased risk for various tumors, can cause disturbances in metabolism, particularly in insulin regulation. The excessive insulin secretion can lead to low blood sugar levels, making hypoglycemia a common concern in these patients.

In contrast, while DiGeorge Syndrome and Trisomy 21 may present with various metabolic issues, they do not have the same strong association with hypoglycemia as Beckwith-Wiedemann Syndrome. Pierre-Robin sequence, while involving a complex of developmental issues mainly related to the jaw and airway, is also less directly connected to hypoglycemia, focusing more on oral and respiratory challenges rather than metabolic syndromes. Thus, Beckwith-Wiedemann Syndrome stands out as the condition with a clearly established connection to significant hypoglycemia.