Which group of infants is most at risk for hypoglycemia?

The group of infants most at risk for hypoglycemia encompasses all of the specified conditions because each can contribute significantly to the development of low blood sugar levels in newborns.

Infants with low hepatic glycogen stores are at risk because glycogen is the primary store of glucose in the body. If these stores are depleted due to premature birth or inadequate nutritional intake, the infant may not have sufficient glucose available for metabolic needs, leading to hypoglycemia.

Infants with hyperinsulinism produce excess insulin, which promotes the uptake of glucose by tissues and decreases blood glucose levels. This condition can lead to a rapid decline in blood sugar if not properly managed, making these infants especially vulnerable to hypoglycemia.

Infants with sepsis experience systemic infections that can interfere with metabolic processes, leading to an inability to maintain adequate glucose levels. The stress response to infection may increase glucose consumption, while poor feeding and the body's energy demands can further exacerbate hypoglycemia.

Since each of these groups has distinct but interrelated factors that predispose them to hypoglycemia, the comprehensive nature of the risk they face justifies the conclusion that all of the options represent infants at heightened risk for this condition.