Which of the following conditions would indicate non-physiologic jaundice?

Non-physiologic jaundice in neonates typically suggests an underlying pathological condition rather than the normal physiological variations seen in newborns. Jaundice that lasts longer than 7 days is a strong indicator of non-physiologic jaundice because typical physiological jaundice usually resolves within the first week of life.

In a healthy, term newborn, bilirubin levels typically start to rise on about the second or third day of life, peak around the fifth day, and then begin to decline. When jaundice persists beyond a week, particularly after the expected resolution time frame, it raises concerns about possible underlying issues such as hemolytic disease, infections, or metabolic disorders that necessitate further evaluation and management.

Other options are reflective of situations that could be associated with normal physiological jaundice. For example, jaundice that appears after 48 hours of birth can still fall within the range of physiological jaundice, as it usually presents within the first week. Similarly, jaundice with bilirubin levels under 10 mg/dL might still be considered a non-threatening level, especially on the earlier side of life, and low albumin levels, while they can indicate various conditions, are not directly correlating to the presence of jaundice. Therefore,