Which of the following factors would cause the oxygen-hemoglobin dissociation curve to shift to the right?

The oxygen-hemoglobin dissociation curve illustrates the relationship between the partial pressure of oxygen (PaO2) and the hemoglobin saturation with oxygen (SaO2). A rightward shift in this curve indicates that hemoglobin has a decreased affinity for oxygen, which promotes the release of oxygen to tissues that are in need.

Increased temperature is known to promote the release of oxygen from hemoglobin because elevated temperatures enhance metabolism, resulting in a need for more oxygen in the tissues. This means that as body temperature rises, the hemoglobin will more readily give up oxygen.

Decreased pH, often caused by increased carbon dioxide or lactic acid, leads to acidosis, which also results in a rightward shift of the curve. This phenomenon, known as the Bohr effect, enhances oxygen unloading where it is most needed, such as in metabolically active tissues.

Increased levels of 2,3-diphosphoglycerate (2,3 DPG) in red blood cells also promote a rightward shift. 2,3 DPG is a compound that binds to hemoglobin and lowers its affinity for oxygen, allowing more oxygen to be released into the tissues.

Since all of these factors—elevated temperature,