Which organism is commonly found in nosocomial infections associated with late onset sepsis?

Staphylococcus epidermidis is frequently implicated in nosocomial infections leading to late-onset sepsis, particularly in premature and critically ill neonates. This organism is part of the normal flora of human skin, which means it can easily contaminate central lines, catheters, and other invasive devices commonly used in neonatal intensive care units. Its ability to form biofilms on medical devices significantly increases its pathogenicity, making infections difficult to treat.

In the context of late-onset sepsis, Staphylococcus epidermidis poses a significant risk, particularly after the first 72 hours of life, when neonates are more exposed to pathogens often acquired in the hospital setting. The organism is typically associated with indwelling devices since it can enter the bloodstream when these devices are either improperly maintained or not handled with strict aseptic techniques.

While other organisms listed may also cause late-onset sepsis, Staphylococcus epidermidis is the most common pathogen identified in this specific context, primarily due to its prevalence and the nature of hospital environments.